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Product Name:

NucleoFill Medium 1×1.5ml

Short Description:

NucleoFill Medium is a polynucleotide-based injectable treatment designed to improve skin quality and hydration. It offers deep bio-restructuring, revitalizing the skin at the cellular level for a youthful and radiant appearance.

Key Features:

• Active Ingredient: Natural polynucleotides (20 mg/ml);
• Product Class: Bio-revitalizant;
• Application Areas: Face, neck, décolleté, hands;
• Syringe/Needle Type: 1.5ml pre-filled syringe; recommended 27G needle or 25G cannula;
• Injection Technique: Linear retrograde, microbolus, fan technique;
• Injection Depth: Medium to deep dermis;
• Effect Duration: Up to 6–9 months, depending on individual skin condition;
• Indications: Treatment of fine lines, dehydrated or loose skin, early signs of aging, improvement of skin texture and elasticity;
• Contraindications: Pregnancy, lactation, active skin infections, autoimmune diseases, known hypersensitivity to ingredients.

Composition:

Promoitalia active substance: natural polynucleotides from salmon DNA, buffered physiological solution.

Product Benefits:

• Deep hydration and visible rejuvenating effect;
• Improves skin texture and elasticity;
• Reduces puffiness and signs of oxidative stress;
• Stimulates collagen production for long-lasting skin renewal.

Packaging:

1 × 1.5ml pre-filled syringe in sterile blister packaging, leaflet, and traceability labels.

Certification:

CE certified, compliant with EU standards for aesthetic medical products.

Caution:

NucleoFill Medium is a professional-use-only product and must be administered by trained and certified medical specialists. Its effectiveness and safety depend not only on the product itself, but also on proper injection technique, understanding of skin anatomy, and individualized patient assessment. Misuse or off-label application may lead to adverse reactions.

NucleoFill Medium: Cellular-Level Renewal for Youthful Skin

In the world of modern aesthetic medicine, there’s a growing demand for injectable treatments that not only improve the appearance of the skin but also support its biological recovery. NucleoFill Medium has positioned itself as a standout option in this space, offering a science-backed, polynucleotide based solution for skin rejuvenation, hydration, and firmness restoration. Whether you’re addressing wrinkles, volume loss, or signs of stress and aging, this product provides a unique path to enhancing skin quality and restoring natural vitality.

What Is NucleoFill Medium?

NucleoFill Medium is an advanced injectable treatment developed by Promoitalia, featuring high-purity natural polynucleotides derived from salmon DNA. These biologically active ingredients are clinically formulated to stimulate cellular repair, trigger the biostimulation process, and protect against oxidative stress. Its high viscosity formulation allows for controlled diffusion and longer-lasting results in the treated area.

Unlike conventional fillers, NucleoFill Medium works at a much deeper level. Rather than simply filling lines, it initiates bio restructuring from within, targeting the signs of tissue degeneration and helping the skin regenerate over time.

How It Works: Cellular Biostimulation and Hydration

At its core, NucleoFill Medium activates multiple biological pathways. First, it supports fibroblast activity to stimulate collagen production. Second, the formulation’s unique hydrophilic structure attracts and retains water molecules, promoting intensive hydration — a key factor in treating dehydrated skin and restoring elasticity.

This dual-action mechanism not only improves skin quality but also results in visible skin renewal, improving skin tone and texture while reinforcing the skin barrier. The product’s antioxidant properties further shield the skin from environmental aggressors, offering long-term protection and prevention of oxidative aging.

When to Choose NucleoFill Medium: Ideal Use Cases

NucleoFill Medium is a versatile solution suitable for both preventive and corrective treatments in aesthetic medicine. It is especially beneficial for patients with:

• Fine or moderate wrinkles;
• Early signs of aging and tissue laxity;
• Loss of firmness and skin elasticity;
• Dullness or lack of hydration in the treated zone;
• Post-acne damage and uneven skin texture;
• Visible stretch marks on delicate areas like the abdomen or thighs.

In addition, its ability to reduce puffiness and improve microcirculation makes it ideal for rejuvenating skin in the under-eye area. These combined benefits provide not just aesthetic improvement, but also a boost in the overall health of the skin.

What Makes NucleoFill Medium Unique?

Unlike traditional dermal fillers, NucleoFill Medium does not focus on volume. Instead, it works through molecular signaling to restore skin architecture from the inside out. Here’s what sets it apart:

1. Cell-level renewal: engages the dermal matrix and encourages regeneration.
2. Deep hydration: retains moisture in the extracellular space to rehydrate from within.
3. Safe and effective: generally well tolerated by most patients, with minimal downtime.
4. Natural-looking results: supports a youthful appearance without excessive plumping.

With its bioactive formulation and broad applicability, NucleoFill Medium is increasingly being recommended as a core product in personalized treatment plans.

Compatibility with All Skin Types and Ages

Another advantage of NucleoFill Medium is its compatibility with various skin types, making it suitable for a wide patient base. It is particularly beneficial for individuals starting their anti-ageing journey in their late 20s to early 40s, where the treatment goals focus on prevention, early correction, and overall improvement in skin quality.

By adapting the dosage and treated area, physicians can tailor treatments for younger skin showing visible signs of stress, or mature skin requiring more intensive regeneration. In both scenarios, patients report a more radiant complexion and a restored youthful glow within weeks.

How It Compares: NucleoFill Medium vs. NucleoFill Strong

While both products come from the same new line of polynucleotide injectables, NucleoFill Medium and NucleoFill Strong serve different purposes.

• NucleoFill Medium is ideal for moderate aging signs, general revitalization, and early intervention.
• NucleoFill Strong is recommended for more advanced wrinkles, severe volume loss, and deep structural damage.

Some patients may benefit from combining both products in a phased protocol, starting with NucleoFill Medium to prepare the skin, then switching to Strong for more intensive results.

What to Expect After Treatment

Immediately following the injection, temporary swelling, redness, or minor sensitivity in the treated area may occur. These are normal, short-lived reactions that typically resolve within 24–48 hours. Over the following weeks, improvements in skin hydration, tone, and elasticity become more apparent.

By the end of a recommended three-session protocol spaced over a month, patients often report:

• Increased firmness and improved skin elasticity;
• A smoother, improved skin texture;
• Reduction in visible fine lines and wrinkles;
• Revitalized tone with improved circulation and clarity.

The cumulative effect leads to a significant improvement in the patient’s confidence and satisfaction with their appearance.

How to Integrate NucleoFill Medium with Other Treatments

NucleoFill Medium can be used alone or in combination with other skincare products and medical aesthetic procedures. For example, it pairs well with microneedling, radiofrequency, or mild chemical peels, enhancing the overall anti-aging effect.

When used strategically in a complete skin rejuvenation plan, it enhances outcomes by addressing both structural integrity and hydration — two foundational pillars of healthy skin.

Who Can Administer the Treatment?

Due to the technical skill required, NucleoFill Medium should only be administered by licensed medical professionals trained in aesthetic medicine. A proper consultation is essential to review medical history, understand treatment goals, and determine appropriate dosage and technique.

Qualified practitioners can customize the protocol to suit each patient’s unique needs, ensuring not just safety but optimal results.

Safety Profile and Considerations

Thanks to its biocompatible ingredients, NucleoFill Medium is generally well tolerated, with minimal risk of allergic reaction or long-term complications. However, like any injectable treatment, certain precautions are necessary:

• Avoid use during pregnancy or breastfeeding
• Do not apply over active skin infections
• Patients with autoimmune conditions should be evaluated individually

With appropriate use, NucleoFill Medium becomes a safe, powerful option in any aesthetic toolkit.

Why Demand for Polynucleotides Is Rising

As the aesthetic industry shifts towards regenerative procedures, polynucleotide based products like NucleoFill Medium are gaining popularity. Patients increasingly value treatments that do more than just conceal signs of aging — they want to reverse them biologically.

Polynucleotides offer that promise, triggering self-repair mechanisms and restoring youthful function to skin cells. This aligns perfectly with the goals of modern anti-ageing medicine.

Where to Buy NucleoFill Medium

If you’re ready to order NucleoFill Medium, it’s essential to choose a trusted distributor. For guaranteed authenticity, proper storage, and timely delivery, we recommend purchasing from the official aesthetic product store PDcosmetics. Whether you’re a practitioner expanding your clinical offerings or an informed patient looking to explore regenerative options, buy NucleoFill from reliable sources to ensure safety and quality.