Prior to treatment: remove joint effusion (use separate syringe), if present. Inject 2mL (full syringe contents) intra-articularly in each affected knee weekly for 3 weeks. Use separate syringes for each knee.
Repeated treatment cycles: not established. Avoid intravascular injection. Avoid strenuous activity within 48hrs after injection. Pregnancy. Nursing mothers.
Avoid disinfectants with quaternary ammonium salts. Concomitant other intra-articular injectables: not recommended.